Carbopol® Ultrez 10 NF Polymer

Carbomer Interpolymer Type A USP NF

Applicable synonyms for Carbopol® Ultrez 10 NF polymer: Carbomer, carboxypolymethylene
Polymerization/residual solvent: Cosolvent mixture of ethyl acetate and cyclohexane

Key Features: 

• Easy to disperse
• Thickener and rheology modifier 

Additional Features:

• Bioadhesive agent
• Emulsion and suspension stabilizer

Recommended for use in the following dosage forms:

• Semisolids & gels
  

Recommended for use in the following markets / routes of administration:

• Topical drug delivery
• Ophthalmic drug delivery

Carbopol® Ultrez 10 NF polymer meets the limits cited in the current edition of the following monographs: 

• United States Pharmacopeia/National Formulary (USP/NF) monograph for Carbomer Interpolymer Type A
• China Pharmacopeia (ChP) monograph for Carbomer Interpolymer

Starting Point Formulations: 

• Ketoprofen Gel 2.5% with Carbopol® Ultrez 10 NF 

Usage Levels: 

• Topical 0.5-3 wt%
  

Note on toxicity testing:

The toxicity of carbomers has been summarized by the Cosmetic Ingredient Review Expert Panel in their assessment of the safety of the carbomers for cosmetic ingredients. This assessment and subsequent toxicology testing have demonstrated a low toxicity and irritation potential. Lubrizol has supporting data for dermal and ophthalmic toxicology testing for Carbopol Ultrez 10 NF polymer. Bulletin 2 provides a summary of all toxicology studies for Lubrizol’s pharmaceutical grade polymers.

Additionally, Lubrizol has filed a Type V DMF with FDA. A letter of authorization (LOA) can be issued for FDA drug applications.